|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lastly, diminished AR expression in spinal motor neurons, which links to another motor neuron disorder, spinal bulbar muscular atrophy (SBMA), may contribute to ALS pathogenesis and suggests a common disease pathway in ALS and SBMA mediated by disruption of AR signalling in motor neurons.
|
25889790 |
2015 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data provide compelling evidence that androgen signalling via the AR in the hypothalamus acts to positively regulate the maintenance of hind-limb muscle mass and voluntary activity in adult male mice, independent of AR signalling in peripheral tissues.
|
30853652 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RANK-mediated signaling established a premetastatic niche through a feed-forward loop, involving the induction of RANKL and c-Met, but repression of androgen receptor (AR) expression and AR signaling pathways.
|
24478054 |
2014 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of androgen receptor (AR) signaling plays an essential role in both prostate stromal cells and epithelial cells during the development of benign prostatic hyperplasia (BPH).
|
29568063 |
2018 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we further characterise p23 roles in AR signalling and show that it modulates cytosolic AR levels in the absence of hormone, confirming a chaperoning function in the aporeceptor complex and suggesting p23 upregulates AR signalling at multiple stages.
|
25241147 |
2015 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In prostate cancer, EMP has been associated with both suppression and activation of the androgen receptor (AR) signaling.
|
28302679 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, FN14 expression was correlated inversely with androgen receptor (AR) signaling output in clinical samples.
|
24970477 |
2014 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is in part through the activation of the androgen receptor (AR) signaling.
|
31477836 |
2020 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To study the regulation of metformin on the biological behaviors of the castration-resistant prostate cancer (CRPC) PC-3 cell such as proliferation, invasion, apoptosis through influencing Notch1/Hes and androgen receptor (AR) signaling pathway activity by its inhibition on the expression of PLCε gene.
|
28485785 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The most significant findings were that ERβ down-regulates androgen receptor (AR) signaling and up-regulates the tumor suppressor phosphatase and tensin homolog (PTEN).
|
28439009 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our previous studies showed that UXT regulates transcription repression including androgen receptor (AR) signaling in prostate cancer.
|
30774773 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing SOD2 expression upregulates androgen receptor (AR) signaling and expression of SOD2 is downregulated in CRPC, compared with untreated tumors.
|
27325180 |
2016 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results showed AR could suppress IL12A expression at the transcriptional level via direct binding to the IL12A promoter region that resulted in repressing efficacy of NK cell cytotoxicity against HCC, and sorafenib treatment could enhance IL12A signals via suppressing AR signals.
|
26939703 |
2016 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of prolactin in the prostate itself (rather than changes in circulating prolactin levels) and crosstalk with androgen receptor (AR) signaling are potential mechanisms for increased Stat5a/b signaling in prostate cancer.
|
21971318 |
2011 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that cell growth would be inhibited with DHEAS/AI treatment after successful transfection of an AR expression vector.
|
16647340 |
2006 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously demonstrated that human H2-relaxin can mediate androgen-independent growth of LNCaP through a mechanism that involves the activation of the androgen receptor (AR) signaling pathway.
|
17653089 |
2008 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Androgen receptor is frequently expressed in various subtypes of ovarian cancers and androgen/AR signaling has been shown to promote proliferation, migration, and invasion of ovarian cancer cells.
|
27741511 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism.
|
29917167 |
2018 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further analysis suggested that increased expression of HSD3B1 and reduced expression of androgen receptor (AR) promoted adaptation to androgen-abundant conditions, as indicated by the increased conversion of DHT into 3β-diol by HSD3B1 and AR signal reduction.
|
23780684 |
2013 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To explore the role of EGR1 in prostate tumorigenesis, we examined the impact of EGR1 expression on the androgen receptor (AR) signaling pathway.
|
12890669 |
2003 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The vast majority of prostate cancer deaths are due to castration-resistant prostate cancer (CRPC) - the lethal form of the disease that has progressed despite therapies that interfere with activation of androgen receptor (AR) signaling.
|
27276681 |
2016 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the role of beta-catenin mutations on androgen receptor (AR) signaling. beta-Catenin significantly enhanced androgen-stimulated transcriptional activation by the AR. beta-Catenin also increased AR transcriptional activation by androstenedione and estradiol and diminished the antagonism of bicalutamide.
|
10987273 |
2000 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Abnormal activation of androgen receptor (AR) signaling pathway is a critical pathogenic mechanism and therapeutic target for prostate cancer (PCa).
|
30058677 |
2018 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The androgen receptor (AR) is expressed in many cell types and the androgen/AR signaling has been found to have important roles in modulating tumorigenesis and metastasis in several cancers including prostate, bladder, kidney, lung, breast and liver.
|
23873027 |
2014 |
|
Aortic Valve Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
"In vitro" experiments suggest that the larger GGN repeats provide a lower AR-protein yield, whereas the larger CAG repeats decrease the AR transcriptional activity, both decreasing the AR signalling intensity.
|
19095061 |
2009 |